In the same year that the first eofad mutation was found in app pericak vance and colleagues reported significant genetic linkage of the more common late onset form of ad 65 years to chromosome 19 pericak vance et al 1991two years later they found a common polymorphism 4 in the gene encoding apolipoprotein e apoe in the same chromosomal region associated with increased risk for . A candid account of one familys twenty year struggle with alzheimers disease the authors wife who has been totally disabled for a number of years has been and continues to be cared for at their house by her husband with some part time helpers although the story is told from a christian point of view it will be useful to all whose lives are touched by this disease which destroys brains with so much practical experience gained in the furnace of affliction the writer has something . Roughly twenty years before the first symptoms of alzheimers disease appear inflammatory changes in the brain can be seen according to a new study from karolinska institutet published in the medical scientific journal brain the findings of the researchers who monitored several pathological changes in the brain suggest that activation of astrocytes at an early stage can greatly . twenty years with alzheimers disease uploaded by john creasey in the same year that the first eofad mutation was found in app pericak vance and colleagues reported significant genetic linkage of the more common late onset form of ad 65 years to chromosome 19 pericak vance et al 1991two years later they found a common polymorphism 4 in the gene encoding apolipoprotein e apoe in the same